Contract Services

Chiral Preparation…HPLC Phase Development…HPLC Method Development…Target Compound Preparation including Peptide, Protein & API Synthesis…Instrumentation Design Services…Technical Market Research

4CHROM, Inc. is proud to announce its partnership with AECS-QuikPrep™ that we may offer these various contract services.  Please let us know your general non-confidential needs during your first contact, and we can then move to a mutually agreeable "e;Confidentiality Disclosure Agreement"e; ( CDA ) prior to detailed discussion of your specific requirements.

Either go to our 'Contact Us' page and initiate the request or feel free to contact us directly by phone Toll Free (866)424-7661 or (919)872-5700. 

• IN OCTOBER 2003, AECS CELEBRATED 20 YEARS OF COMMERCIAL ANALYTICAL, PREPARATIVE AND PROCESS CONTRACT RESEARCH.

• PROJECTS INCLUDED : HPLC PHASE DEVELOPMENT / METHODOLOGY DEVELOPMENT / CONTRACT TARGET COMPOUND PREPARATIONS INCLUDING PROTEIN, PEPTDIE & API SYNTHESIS/ CONTRACT INSTRUMENTATION DESIGN / TECHNICAL MARKET RESEARCH.

• AECS IS ONE OF THE FEW INTERNATIONAL CHROMATOGRAPHY PREPARATIVE SPECIALISTS WITH EXPERIENCE IN ALL ASPECTS OF COUNTERCURRENT, LOW / HIGH PRESSURE LIQUID CHROMATOGRAPHY INSTRUMENTATION DESIGN AND THE USE OF THESE TECHNOLOGIES FOR TARGET COMPOUND PREPARATIONS.

Why not let us assist you to choose the most cost-effective preparative technology choice for your specific needs…?

Alternatively let us undertake your contract method development and / or target compound preparative chromatography…?

Require GMP contract synthesis for… Human Clinical Trials…?

Facilities & Project Type

• Quaternary preparative HPLC pumps and photodiode array detectors utilizing AECS's own design of high-resolution preparative column technology.

• Compare the efficiency of AECS's preparative column’s which are typically between 60,000 to 100,000 p/m ……….To those of our competitors, many of whom still use old fashion low efficiency preparative columns, often with only 10,000 p/m.

• HPLC preparations of both Achiral & Chiral target compounds undertaken.

• Off-line TLC or bioassay or analytical HPLC or MS or LC/MS/MS to support preparative bio-activity / purity assessments.

• Quattro QuikPrep™ and LabPrep™ Countercurrent Chromatographs with various coil volumes and coil bore id's are available.

• Custom Countercurrent Chromatographs can be designed and built for any laboratory, pilot or process application.

• AECS can undertake the chromatography feasibility study, technical and cost analysis benefit determination, custom design and build, plus install / train staff / commission the custom design in client’s facility.

• Gyan Flash Chromatographs.

• Full support of specialist GMP Synthesis / Preparation Laboratory with LC/MS/MS if required.

• Contract GMP synthesis scale-up from Milligram to 2 or 3+ KG projects can be quoted per GMP suite. Larger projects also accommodated.  Facility fully accredited for manufacture of Active Pharmaceutical Ingredients for use in Human Clinical Trials


Worth Thinking About ?  Require More Information…?

Technical Support

Whether you are looking to get help troubleshooting an existing equipment problem or investigate ways to reduce downtime, 4CHROM is available to assist. Feel free to contact us by e-mail, phone, or fax with as much detail as you are able to provide and we will promptly follow up.

Training

4CHROM is excited about our new classes for HPLC.  Repeatedly we interact with customers helping to troubleshoot method or instrumentation problems.  And often, customers comment that they wish someone offered a class covering some of the topics or issues addressed through our field and phone support.  Due to the nature of business today, 4CHROM is glad to offer these classes at your site:

Introduction to HPLC & Troubleshooting HPLC

Less Costly: Most training classes are offered at some remote location often requiring travel expenses or at minimum, added time away from the lab.  4CHROM's classes are provided at your location.  Our rates are usually lower as well.  We may not have the name of some course instructors, but the content of our classes is what you pay for and receive.  Each class is $750 for the first ten attendees and $100 for each additional attendee plus travel expenses.

More Convenient: Since the classes are provided at your location and scheduled at times convenient for your staff, the negative impact on your company's workload is minimized.

More Flexible:  Each of our classes can be geared more toward the background of your staff.  The length of each course can be geared to meet your company's needs (usually the courses are 4 hours long).

More Comfortable:  Most people are more likely to ask questions around their friends than around strangers.  This should result on a better understanding of the course material and a greater comfort with the subject matter.

Introduction to HPLC

We have designed "e;Introduction to HPLC"e; to cover the major topics necessary to gain a solid grasp of HPLC.  The course covers the following topics:
1. Chromatography Fundamentals
2. Solvents
3. Columns
4. Solvent Delivery System
5. Detectors & Data Collection
6. Method Development
7. Review & Quiz

Troubleshooting HPLC

This course teaches both how to solve HPLC problems and how to prevent them.  Both are important at reducing costs and individual frustrations.  Each attendee will discover that all the aches and pains of running HPLC methods have simple causes and therefore simple solutions.  The course covers the following topics:
1. Introduction
2. Troubleshooting Approach
3. Pressure Problems
4. Leaks
5. Component Malfunctions
6. Baseline Problems
7. Peak Problems
8. Data Problems
9. Review & Quiz

Repair, Maintenance & Calibration Services

Through various service partners, 4CHROM can provide repair, mai n tenance, and calibration services as needed.   Contact us for a service provider near you.